![]() This association was primarily influenced by the appliance dead space. V D,MM/ V T was negatively associated with GA after adjusting for birth weight Z score (p < 0.001, R 2 = 0.26). Tidal breathing variables were analysed using multivariable linear regression. ![]() Results: Valid measurements were obtained in 43/51 (87%) infants. Tidal breathing analysis was performed in ventilated very preterm infants (GA range 23-32 weeks) on day 1 of life. Methods: This was a single-centre, prospective, observational, cohort study in a neonatal intensive care unit. Objectives: We aimed to calculate respiratory dead space ( V D) from the molar mass (MM) signal of an ultrasonic flowmeter ( V D,MM) in very preterm infants on volume-targeted ventilation ( V T target, 4-5 ml/kg) and to study the association between gestational age (GA) and V D,MM-to- V T ratio ( V D,MM/ V T), alveolar tidal volume ( V A) and alveolar minute volume (AMV). ![]() The optimal ventilator-delivered tidal volume ( V T) in these infants is unknown and may depend on the extent of alveolarisation at birth. Background: Ventilated preterm infant lungs are vulnerable to overdistension and underinflation.
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